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Bioanalytics
Keynote

Keynote: New Frontiers in High Performance Mass Spectrometry for Bioanalysis of Therapeutics

Wednesday, November 12, 2025
1:30 PM - 2:30 PM CT
Location:221 CD

Bioanalytics

Mass spectrometry has become one of the premier analytical tools for characterization and evaluation of biopharmaceuticals. Mass spectrometry can be used to determine binding stoichiometry, cooperativity, affinity and competition for protein-inhibitor interactions. The development of innovative strategies continues to advance the range of applications of mass spectrometry for characterizing antibodies, antibody drug conjugates, and protein targets that interact with small molecule inhibitors or newer modalities such as PROTACs. This presentation will focus on new mass spectrometry methods, including ultraviolet photodissociation, proton transfer charge reduction, and native top-down techniques, to characterize proteins, protein complexes, and protein interactions important for development of biopharmaceuticals.

Learning Objectives:

  • Understand the development and applications of innovative mass spectrometry strategies for characterization of antibodies, antibody drug conjugates, and protein-inhibitor binding interactions.
  • Develop familiarity with ultraviolet photodissociation mass spectrometry as an alternative to conventional tandem mass spectrometry methods.
  • Understand how native mass spectrometry to evaluate binding stoichiometry, cooperativity, affinity and competition.