This study explores the use of two semi-solid extrusion (SSE)-based 3D printing methods, pneumatic and syringe-based, for fabricating orodispersible films (ODFs), which rapidly dissolve in saliva and are ideal for patients with swallowing difficulties. Both methods produced consistent, high-quality films with excellent mechanical and dissolution properties. Syringe-based extrusion offered higher precision, while pneumatic extrusion enabled faster production. The findings support the feasibility of both technologies for personalized ODF manufacturing in pharmaceutical and clinical settings.
Learning Objectives:
Understand the feasibility and advantages of different extrusion-based 3D printing technologies for fabricating orodispersible films (ODFs).
Evaluate the process variables such as drying time, temperature, and nozzle type on the disintegration, and mechanical properties of ODFs.
Explore the role of polymer and excipient combinations in enhancing film stability, drug content uniformity, and personalization potential in ODF formulation.
