Assistant Professor & Principal Investigator University of Groningen Groningen, Groningen, Netherlands
The use of biodegradable particles for mRNA delivery is revolutionizing genetic therapies by facilitating durable and controlled expression of therapeutic proteins. These systems are crucial for ensuring mRNA stability and efficient delivery to target cells, resulting in prolonged therapeutic protein expression. With applications in oncology, immunology, and gene therapies, biodegradable particles offer a sustainable method for mRNA delivery while minimizing toxicity. This session will discuss the design and advantages of biodegradable particles, exploring their potential in the development of mRNA-based vaccines, cancer immunotherapies, and gene editing, with a focus on aggressive glioblastoma. Formulation and translational aspects will be covered in this talk, ensuring that attendants get a good idea of the high risk - high gain scenario in long-acting particle-based RNA delivery.
Learning Objectives:
Understand the design of biodegradable particle systems to enable durable and controlled expression of mRNA-based therapies.
Evaluate the advantages and challenges of particle-based mRNA delivery in applications such as vaccines, cancer immunotherapy, and gene editing.
Navigate formulation and translational considerations for developing long-acting RNA delivery platforms, particularly for high-risk indications like glioblastoma.
