Professor Purdue University West Lafayette, Indiana
Excipients play a vital role in tablet manufacturing by fulfilling a range of functions. However, the distinct roles of lubricants and anti-adherents are often confused, potentially leading to formulation challenges. In this study, we show that internally added hydrogenated vegetable oil (HVO) effectively reduces ejection force but exacerbates punch sticking. Thus, while HVO functions well as a lubricant, it does not act as an anti-adherent. This case study underscores the importance of accurately classifying excipients based on their functional roles, thereby guiding more effective excipient selection for the formulation of tablets with improved manufacturability.
Learning Objectives:
Upon completion, participant will be able to clearly understand distinction between lubricants and anti-adherents.
Upon completion, participant will be able to clearly understand the importance of proper excipient selection for successful tablet manuafacturing.
Upon completion, participant will be able to gain better understanding on functionality of a lubricant, HVO
