Research and Development Leader Inaedis, Inc. Princeton, New Jersey
Room-Temperature Aerosol Dehydration (RTAD) technology represents a breakthrough enabling platform for transforming liquid biologics and vaccines into shelf-stable, bioactive powders without cold chain requirements. Developed at Princeton University and commercialized by Inaedis, Inc., this cGMP-compatible process gently generates aerosols of sub-20 µm droplets that flash-evaporate at room temperature, preserving biomaterial potency while eliminating thermophysical stress.
RTAD supports diverse therapeutic platforms including proteins, antibodies, viral vectors, mRNA-lipid nanoparticles, live-attenuated vaccines, bacteriophages and subunit formulations. Additionally, the technology enables high-concentration suspension formulations of biologics compatible with prefilled syringes and autoinjectors, reducing dose volumes and facilitating multi-antigen delivery. RTAD-produced powders accommodate versatile delivery methods: inhalation via nebulizers, dry powder inhalers, transdermal administration, and subcutaneous administration.
This formulation innovation addresses critical stability challenges across oncology, gene therapy, and vaccination applications. By eliminating cold chain dependency and enhancing thermal stability, RTAD expands therapeutic access to underserved populations while improving patient compliance through flexible delivery platforms.
Learning Objectives:
Upon completion, participant will be able to describe Room-Temperature Aerosol Dehydration technology principles and benefits and differentiate its sub-20 µm droplet flash-evaporation mechanism from conventional spray drying and lyophilization methods.
Describe the manufacturing advantages of RTAD, including its ability to process high-concentration commercial formulations at room temperature without requiring dilution or additional excipients.
Summarize the quality attributes of the resulting bevacizumab powder produced by RTAD, such as its biological activity, long-term stability at room temperature, and particle morphology.
