Associate Principal Scientist IQVIA Laboratories Ithaca, New York
This presentation will describe a validation of a bioanalytical assay for a siRNA therapeutic in dried blood microsamples. Volumetric approaches to micro sampling provide a significant improvement in analytical results and these devices are being employed more widely in the clinical sample collection process. These devices have several benefits for a patient centric approach or use in decentralized clinical trials. Therapeutic siRNA drugs have also become prominent in the industry. This work is a demonstration of the assessment of these devices and the validation of their use for clinical sample analysis in combination with this molecule class.
Learning Objectives:
Upon completion, participants will be able to understand the method used to validate the bioanalytical assay for extraction and LC-MS/MS analysis of an siRNA therapeutic target from dried mircroasmples.
Upon completion, participants will be able to understand the use and purpose of employing microsampling collection devices.
Upon completion, participants will be able to better define experiments to include in validation of an assay for dried blood samples.
