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Formulation and Delivery
Partner Presentation

High Purity Excipients and Lipids in Enabling Advanced Drug Delivery

Tuesday, November 11, 2025
10:30 AM - 11:30 AM CT
Location:360 Stage #3, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

This presentation examines the impact of excipient purity on formulation performance across small molecules, proteins, and nucleic acids. A high-purity dimethyl isosorbide enhances dermal permeation with improved stability in topical small molecule systems. Case studies reveal the role of polysorbate in mitigating surface-induced protein destabilization, and the advantage of high purity surfactants in improving drug stability. Purified surfactants also stabilize RNA-loaded lipid nanoparticles against physical stress by preventing particle leakage and aggregation.

Learning Objectives:

  • Understand how excipient purity influences stability along with permeation and bioavailability in topical drug delivery.
  • Investigate the impact of surfactant purity on formulation stability and strategies to mitigate enzymatic degradation
  • Assess the role of purified surfactants in stabilizing LNP formulations for nucleic acid delivery upon mechanical shaking and freeze-thawing.