Skip to main content
2025 PharmSci 360 Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Listen Now

Formulation and Delivery
Partner Presentation

High Purity Excipients and Lipids in Enabling Advanced Drug Delivery

Tuesday, November 11, 2025
10:30 AM - 11:30 AM CT
Location:360 Stage #3, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

Description: This presentation examines the impact of excipient purity on formulation performance across small molecules, proteins, and nucleic acids. A high-purity dimethyl isosorbide enhances dermal permeation with improved stability in topical small molecule systems. Case studies reveal the role of polysorbate in mitigating surface-induced protein destabilization, and the advantage of high purity surfactants in improving drug stability. Purified surfactants also stabilize RNA-loaded lipid nanoparticles against physical stress by preventing particle leakage and aggregation.

Learning Objectives:

  • Understand how excipient purity influences stability along with permeation and bioavailability in topical drug delivery.
  • Investigate the impact of surfactant purity on formulation stability and strategies to mitigate enzymatic degradation
  • Assess the role of purified surfactants in stabilizing LNP formulations for nucleic acid delivery upon mechanical shaking and freeze-thawing.