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Formulation and Delivery
Partner Presentation

Improving Physicochemical Properties of Drug Substance via Co-Processing Techniques

Tuesday, November 11, 2025
1:30 PM - 2:30 PM CT
Location:360 Stage #1, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

    Partner Presentation Speaker(s)

  • Harsh Shah, Ph.D.

    Associate Director
    Porton
    Cranbury, New Jersey

Description: This presentation highlights the application of co-processing strategies to improve flowability and bulk density of micronized APIs as well as solubility improvement for poorly soluble APIs. While co-precipitation technology and heterogeneous nucleation were evaluated for flow properties improvement, Coprecipitated amorphous dispersion (CAD) was studied for solubility improvement, through systematic screening, optimization, and scale-up. Key outcomes include identification of robust polymer/solvent systems, successful generation of free-flowing spherical agglomerates, and demonstration of scalability with regulatory-compliant solvent residues.

Learning Objectives:

  • Understand how co-processing technologies can enhance flow properties and/or improved solubility of APIs.
  • Gain insights into systematic screening and process optimization strategies for CPT, heterogeneous nucleation, and CAD approaches.
  • Evaluate the scalability and practical considerations of applying co-processing for drug substance–drug product interface development.