2025 AAPS High Impact Manuscript Award Rapid Fire Presentations
Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated Intradermal Delivery of Long-acting Rilpivirine and Cabotegravir Nanosuspensions for Paediatric HIV Antiretroviral Therapy
Tuesday, November 11, 2025
2:35 PM - 2:50 PM CT
Location: Spotlight Stage A, Aisle 2500, Exhibit Hall
Professor Queen's University Belfast Belfast, Northern Ireland, United Kingdom
This talk illustrates the potential of a dissolving microneedle platform to repeatedly maintain plasma concentrations for rilpivirine and cabotegravir. As such, these systems could represent a viable option to improve adherence in the paediatric population, one that is capable of being painlessly administered in the comfort of the patient’s own home on a biweekly or even less frequent basis.
Learning Objectives:
Understand the use of drug nanocrystals in long-acting drug delivery
Consider how nanocrystals can be delivered intyradermally using dissolving microneedles
Review pharmacokinetic data on repeated administration of rilpivirine and cabotegravir in rats
