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Formulation and Delivery
Chalk Talk

Critical Factors in Choosing Closure Systems for Frozen Biotherapeutics

Monday, November 10, 2025
12:30 PM - 1:15 PM CT
Location:Spotlight Stage A, Aisle 2500, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

Description: With the advent of the biotechnology era and the growing prevalence of frozen biologic drug products, a systematic framework for container–closure system selection is critical. Such a framework must address the complex interactions among formulation, container, and closure components and employ rapid screening techniques—such as fractographic analysis—to ensure container integrity during product release and throughout long-term storage.

Learning Objectives:

  • Selection of an appropriate container closure system for frozen biologics products is super critical and profoundly impacts the Drug product performance and stability.
  • Container closure system selection demands consideration of both formulation design and container closure variables:
  • Understand the interaction between formulation design and container closure systems