Formulation and Delivery

Enhancing Formulation Development with Algorithm-Based Excipient Selection Platform

Partner Presentation Speaker(s)

• HS

  Harsh Shah, Ph.D.

  Senior Scientist, Pharma Solutions
  BASF Corporation
  Tarrytown, New York
• CB

  Connor Bilchak, PhD

  Scientist
  BASF
  Tarrytown, New York

Drug–polymer miscibility is crucial for stable amorphous solid dispersions (ASDs) to enhance solubility and bioavailability of poorly soluble drugs. Poor miscibility risks phase separation and reduced performance. Digital formulation tools can play a crucial role in enabling rational excipient selection, providing miscibility prediction, and expediting data-driven formulation design. A case study with Hot Melt Extrusion (HME) highlights how virtual formulation assistants can streamline polymer selection, improves stability, and reduces developmental time and risk in ASD development.