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Formulation and Delivery
Chalk Talk

Low-Substituted Hydroxypropyl Cellulose: A Dual Binder–Disintegrant in Twin-Screw Wet Granulation

Monday, November 10, 2025
2:45 PM - 3:30 PM CT
Location:Spotlight Stage C, Aisle 3800, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

    Chalk Talk Presenter(s)

  • David Nakhla, PhD

    Application Lab Manager - Formulation Scientist
    Shin-Etsu
    Totowa, New Jersey

Twin-screw wet granulation (TSWG) offers a continuous manufacturing approach for enhancing the flowability and compressibility of poorly flowable APIs. Low-substituted hydroxypropyl cellulose (L-HPC), incorporated intra-granularly, provides multifunctional performance as a binder, disintegrant, and moisture scavenger. This study systematically investigates critical process and formulation parameters, applying L-HPC within TSWG to establish optimal conditions that enable robust granule formation, efficient downstream processing, and consistent quality of oral solid dosage forms.

Learning Objectives:

  • Understand the unique chemistry of L-HPC that enables dual binder-disintegrant functionality and supports API stability.
  • Identify key process and formulation parameters for effective application of L-HPC in twin-screw wet granulation (TSWG).
  • Evaluate case studies demonstrating L-HPC application in TSWG across different APIs to improve flowability, compressibility, and tabletability.