Advanced In Vitro GI Simulation and Biopharmaceutics Modeling (PBPK/PBBM) to Support Oral Drug Development

Monday, November 10, 2025

4:00 PM - 4:45 PM CT

Location:Spotlight Stage C, Aisle 3800, Exhibit Hall

Sponsored By

Partner Presentation Speaker(s)

CO

Connor O'Farrell, Ph.D.

Senior Scientist
InnoGI Technologies
Delft, Zuid-Holland, Netherlands

Description: Advanced in vitro gastrointestinal (GI) models simulate the physiology of the GI tract, offering mechanistic insights into oral drug product behavior. Physiologically-based biopharmaceutics modelling (PBBM) is a pharmacokinetic modelling approach, with a focus on drug product behavior in the GI tract driven by experimental dissolution input.

Learning Objectives:

Learn how advanced in vitro GI models can be valuable to formulation development and candidate selection, particularly for products containing poorly soluble APIs or complex release mechanisms.
Learn how co-administration of drug products to in vitro models with real food allows for the investigation of complex food effects on drug performance, whether using standardized meals, pediatric soft foods or customized meals.
Learn how biorelevant in vitro models combined with PBBM enable predictive insights into the effects of formulation and physiology on predicted drug exposure, enhancing risk assessment granularity, reducing clinical bridging needs, and promoting a deeper understanding of drug product performance.