Rational Design of Self-emulsifying Drug Delivery Systems Using Hydrophile-Lipophile Difference

Monday, November 10, 2025

3:30 PM - 4:30 PM CT

Location:360 Stage #2, Exhibit Hall

Sponsored By

Partner Presentation Speaker(s)

CB

Connor Bilchak, PhD

Sientist
BASF
Tarrytown, New York
Rainer Dobrawa, Ph.D. (he/him/his)

Global Marketing Director
BASF
Florham Park, New Jersey

Description: Lipid-based drug delivery systems such as SEDDS are a well-established approach for drug delivery; however, their large design space – (co-)surfactant(s), API type and content, lipid(s), etc. – complicates formulation design. Here, we introduce a digital workflow utilizing Hydrophile-Lipophile Difference/ Net-Average Curvature (HLD-NAC) to predict emulsion phase behavior for rational SEDDS design. We demonstrate the utility of this using in-silico formulation tools to design and experimentally verify a fully-dilutable SEDDS formulation.

Learning Objectives:

Describe and apply basic HLD-NAC concepts for emulsion design
Examine use-cases of HLD-NAC assisted emulsion design
Design and assess SEDDS formulations using HLD-NAC enabled in-silico workflows