.jpg "Mengyue Li, MS photo")
Graduate Research Assistant
University of Kansas
Mengyue Li am a PhD student in the Department of Pharmaceutical Chemistry at the University of Kansas. Her research focuses on understanding ocular drug metabolism and disposition through transcriptomic and proteomic profiling of drug-metabolizing enzymes and drug transporters in ocular sub-tissues, with comparisons to major metabolic organs such as the liver and duodenum. Additionally, she conduct ocular pharmacokinetic (PK) studies using dual-probe microdialysis in a rabbit model and develop LC-MS/MS methods for quantifying small molecules and bottom-up proteomics. The ultimate goal of her research is to develop an ocular physiologically based pharmacokinetic (O-PBPK) model incorporating latanoprost PK data and ocular-specific CES expression profiles to improve predictions of latanoprost pharmacokinetics in humans.