Faculty/Professor
Creighton University
After earning a Masters of Pharmacy from Pune University (India) in 1998, I worked as a synthetic chemist and taught medicinal chemistry for three years before beginning a PhD at the University of Nottingham (UK). In the five years after his Ph.D., I worked as a post-doctoral research fellow on three projects: one on cancer research, financed by the BBSRC in the UK; another on drug discovery, funded by the Wellcome Trust; and third one on osteoporosis, funded by the MRC in the UK.
After that for about two years I worked as a senior research scientist at GlaxoSmithKline's RD Alternative Discovery & Development (Madrid Trescantos, Spain) on a collaborative project that involved structural optimization of the hPDE4 inhibitor GSK675728A to produce novel pharmacophore(s) as potent TbrPDE1 inhibitors that are selective over hPDEs in the management of African sleeping sickness (CNS disorder).
I joined Creighton University in June 2016 as a postdoctoral researcher and later promoted to assistant professor of medicinal chemistry in early 2017. Currently, I am tenure track faculty in the school of medicine working under Dr. Peter Abel.
Lab Research Focus: Dr. Jadhav’s Lab is aimed at;
A) Molecular docking and Structure Activity Relationship (SAR) based small molecular drug discovery to tackle biological problems such as Neuroinfllamatory disorders, Cancers, Noise induced hearing loss (NIHL) and Antibiotic resistant Bacterial infections. Current projects involve (1) Development of Triggering receptors expressed on myeloid cells-1 (TREM1) inhibitors to treat neuronal disorders, NIHL and liver cancer. (2) Development of small molecules as Mvfr inhibitors to treat antibiotic resistant Pseudomonas aeruginosa infections.
B) Development of small molecules drug like candidates against antibiotic reststant Pseudomonas aeruginosa infections.
C) Dual conjugates of Latanoprost acid to release Nitrous oxide (NO) and Hydrogen suflide (H2S) in the management of gloucoma.