PhD Candidate
Massachusetts College of Pharmacy and Health Sciences
Ishan Shah, PhD Candidate, is a Graduate Research Assistant in the Department of Pharmaceutical Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences (MCPHS), Boston. His doctoral research is centered on the design and development of cancer vaccines with an emphasis on transdermal delivery via microneedle platforms. His work integrates nanotechnology, immunology, and drug delivery science to address the pressing need for safer and more effective vaccination strategies in oncology.
Mr. Shah’s current project focuses on formulating PLGA-based nanoparticles encapsulating tumor-associated antigens such as NY-ESO-1, along with immune adjuvants, and embedding them into biodegradable polymeric microneedle arrays for minimally invasive administration. His research involves characterizing nanoparticle physicochemical properties, optimizing antigen stability, conducting in vitro release studies, and evaluating immunomodulatory responses in immune cell models. By combining controlled release technology with transdermal systems, his long-term goal is to enhance vaccine efficacy while reducing systemic toxicity and improving patient compliance.
In addition to his research, Mr. Shah has gained significant teaching experience at MCPHS. He has served as a Teaching Assistant in Basic Chemistry labs and Dosage Form courses, and as Head TA for exam management in the School of Pharmacy. These roles allowed him to mentor undergraduate and professional students, strengthen his leadership skills, and contribute to the academic mission of the department.