Bioanalytics - Biomolecular

(M0930-01-01) The Impact of Oxidative Modifications on the Bioavailability of Subcutaneously Administered Therapeutic Monoclonal Antibodies

(M0930-01-02) A Low Level, Carryover Free and Wide Range, LC-MS/MS Method for Quantitation of Semaglutide from Human Plasma

(T0930-01-02) Advancing Biomarker Assay Validation: From Supportive Secondary Endpoint to Primary Endpoint for Regulatory Decision Making in Generalized Myasthenia Gravis

(T0930-01-03) Investigating How Ionizable Lipids Impact the Cargo RNA Organization in Lipid Nanoparticles Using Small Angle X-Ray Scattering (SAXS)

(M0930-01-03) The Tale of Two Methods: Understanding the Roles of IEX and icIEF for Monitoring Charge Heterogeneity of Stressed Biotherapeutics

(M0930-01-04) Cell Line–Anchored H-Score Strategy Defining Claudin-6 Expression Patterns in Ovarian Cancer

(M0930-01-05) Novel Light Scattering Solutions for Accelerating Development of Antibody-Drug Conjugates

(T0930-01-05) Targeting SA-85 Trans-Sialidase with VLP-Based Peptides: A Promising Immunologic Strategy Against Chagas Disease

(T0930-01-06) Improved SPR Signal Enhancement in Bioanalytical Assays Using Micropolymer-Conjugated IHC Reagents

(T0930-01-07) Development and Validation of a Colorimetric Assay for Quantification of N-acetyl-β-D-glucosaminidase in Human Urine Using NAG-Based Calibration Standards and Quality Controls

(T1030-01-01) Feasibility of Adding Volumetric Absorptive Microsampling (VAMS®) Using Mitra® Tips to an Established ELISA Assay to Determine Concentrations of a Monoclonal Antibody in Whole Blood

(M1030-01-03) Integrated High-Throughput Platform for Covalent Inhibitor Screening and Characterization

(T1030-01-05) A Validated Hybridization LC-MS/MS Method for Quantitative Bioanalysis of HT-KIT, a Vivo-Morpholino Antisense Oligonucleotide

(M1030-01-05) Enantiomeric and Regioisomeric Separation of Triacylglycerides in Liver Samples from Doxorubicin-Treated Rats Using LC-ESI-MS with Coupled CHIRALPAK IF3 Columns

(M1030-01-06) Comparison of Novel Whole Blood Preservation Methods as Alternatives to Cryopreserved PBMC for Immunophenotyping in Multicenter Clinical Trials

(T1030-01-06) Generic ADA Method Development for Preclinical Study

(T1030-01-07) Development of an Immunoassay to Evaluate Transgene Product Expression from an Investigational Gene Therapy to Treat Dry Age-Related Macular Degeneration (dryAMD) in Various Non-clinical Studies

(M1130-01-01) Development and Validation of a Sensitive LC-MS/MS Method for the Quantification of SGR-1505 in Human Plasma to Support Clinical Pharmacokinetic Studies

(M1130-01-02) Can Microsampling Devices Coupled with Intact Mass High-Resolution Mass Spectrometry Improve M-Protein Monitoring and Simplify Minimal Residual Disease Assessment in Multiple Myeloma?

(M1130-01-03) Custom MSD U-PLEX for the Quantitation of CXCL3, CXCL5, and CXCL10 in Human CSF

(T1130-01-03) Sensitive LC-MS/MS Method for Cationic Ligand-Conjugated siRNA Therapeutics

(M1130-01-04) Evaluating the Impact of Matrix on Ex Vivo Stimulation Flow Cytometry in Bioanalysis

(T1130-01-05) CYFRA21-1 Sensing Gold Nanoparticles Based Diagnostic Kit for Non-Small Cell Lung Cancer

(M1130-01-05) Determination of the Concentration of Recombinant Human Heparan-N-Sulfatase (rhHNS) in Human Serum Using a Ligand Binding Assay (LBA)

(M1130-01-06) Challenges and Solutions in Ion-Pair Reversed-Phase LC–MS/MS Assays for the Quantitation of Novel Oligonucleotides: A Case Study

(M1230-01-01) Determination of One Significant Protein in Human Cerebrospinal Fluid (CSF) by LC-MS/MS

(T1230-01-02) A Validated Assay for LC-MS/MS Analysis of an siRNA Therapeutic Drug Using Microsampling Devices

(M1230-01-03) Optimized PEG-Biotin Functionalized QCM-D Sensor for Rapid Detection of a Sepsis-Associated Biomarker

(T1230-01-04) Method Development and Validation of an Antidrug Antibody Assay for a Novel Bispecific Biotherapeutic – Overcoming Challenges from Pre-Existing Antidrug Antibody and Target Interferences

(M1230-01-05) Rapid and Reproducible TAb/NAb anti-AAV Assays Across Serotypes and Species to Support Global Preclinical Programs

(M1230-01-07) Development, Optimization and Qualification of an IFN-γ ELISPOT Assay for Human PBMCs

(T1330-01-01) Identification of Vendor-Specific Interactions in Antibody HRP Conjugates that Impact Bioanalytical Assay Performance

(M1330-01-01) Quantitation of Total and Free Cortisol in Cynomolgus Monkey Serum Using LC-MS/MS

(M1330-01-02) Biomarker Assay Development and Qualification for Measurement of 5-Methylthioadenosine and Symmetric Dimethylarginine in Human Matrices Using One-Sample Multi-point External Calibration Curve Approach

(T1330-01-04) Pre-Formulation Characterization and Stability Evaluation of a Novel Peptide-Based Drug for Triple-Negative Breast Cancer Treatment

(T1330-01-05) CTLA4 SPLEX Assay Validation and Analysis on Disease and Healthy Donor Sample

(M1330-01-06) Challenges in Developing LC-MS/MS and LC-UV Methods for Modified MicroRNAs: A Case Study of Two RNA Mimics and an Inhibitor with Antiasthmatic Potential

(T1330-01-07) A Novel LC-MS/MS-Based Method for Quantification of Human Serum Properdin: Development, Qualification, and Validation

(M1330-01-07) Critical Insights into Method Qualification for Virus-Like Particle (VLP) Blockade Assays to Human Norovirus

(M1530-01-02) Game of Clones – Investigating the Implications of Mouse Strain and Adjuvant Selection on Sequence Diversity of Monoclonal Anti-ID Reagents

(T1530-01-02) Maximizing Reproducibility and Sensitivity in qPCR for Detecting Transcripts Over a Broad Dynamic Range in Response to Anti-PD-1 Therapy

(T1530-01-03) The Development and the Applications of a Multiple Reaction Monitoring (MRM) Method for Bile Salt Export Pump (BSEP) Measurements in In Vivo and In Vitro Models for Early-Phase Drug Development

(T1530-01-04) Multi-Attribute Quantification of mRNA-Lipid Nanoparticle Therapeutics Using Light Scattering

(M1530-01-04) Resolving Adsorption in Urine Based Kidney Biomarker Assays

(M1530-01-05) Comparative Analysis of Replication-Competent Vector Quantification: Whole Blood vs. PBMCs in Gene Therapy Monitoring

(T1530-01-07) Singlicate Analysis of Anti-Antigen IgA in Human Serum with Ligand-Binding Assay